Journal: medRxiv
Article Title: Comparative Evaluation of Microstructural Diffusion Methods in Characterizing Multiple Sclerosis Lesions: The Importance of multi-b shells acquisition
doi: 10.64898/2026.03.15.26348428
Figure Lengend Snippet: Group comparisons of diffusion metrics across five white matter tissue types in MS and HC. Tissue classes included cBHs (chronic black holes), T2-lesions, cBHs-NAWM and T2-NAWM (normal-appearing white matter), and NWM (normal white matter). Diffusion metrics were derived from DTI (fractional anisotropy [FA], mean diffusivity [MD], axial diffusivity [AD], radial diffusivity [RD]), DKI (axial kurtosis [AK], mean kurtosis [MK], radial kurtosis [RK]), SMT (intra-axonal signal fraction [ V ax ], extra-axonal diffusivity [ D ex ]), NODDI (intracellular volume fraction [ ficvf ], isotropic volume fraction [ fiso ], orientation dispersion index [ odi ], kappa ), and SMI (intra-axonal fraction [ f ], intra-axonal diffusivity [ D a ], extra-axonal parallel diffusivity [ ], extra-axonal perpendicular diffusivity [ ], fiber orientation coherence [ p 2 ]).
Article Snippet: In contrast, DKI, SMT, NODDI and SMI were estimated from multi-shell diffusion MRI data using a MATLAB-based DKI estimator( https://www.mathworks.com/matlabcentral/fileexchange/65487-diffusion-kurtosis-imaging-estimator ), an open-source SMT toolbox ( https://github.com/ekaden/smt ), the NODDI MATLAB toolbox ( http://mig.cs.ucl.ac.uk/index.php?n=Tutorial.NODDImatlab ) and the NYU Diffusion MRI Group SMI toolbox ( https://github.com/NYU-DiffusionMRI/SMI ), respectively.
Techniques: Diffusion-based Assay, Derivative Assay, Dispersion